Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events

  • US RE38,743 E1
  • Filed: 05/07/2003
  • Issued: 06/14/2005
  • Est. Priority Date: 06/26/1990
  • Status: Expired due to Term
First Claim
Patent Images

1. A heterogeneous intimate admixture of sulfated heparinic polysaccharides, such sulfated polysaccharides having a weight average molecular weight less than that of heparin and said admixture consisting essentially offrom 9% to 20% of polysaccharide chains having a molecular weight less than 2,000 daltons, from 5% to 20% of polysaccharide chains having a molecular weight greater than 8,000 daltons, and from 60-86% of polysaccharide chains having a molecular weight of between 2,000 and 8,000 daltons, the ratio between the weight average molecular weight and the number average molecular weight thereof ranging from 1.3 to 1.6 said admixture (i) exhibiting a bioavailability and antithrombotic activity greater than heparin and (ii) having an average molecular weight of between approximately 3,500 and 5,500 daltons.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×