Methods of use for inhibiting bone loss and lowering serum cholesterol
DC
First Claim
1. A method of inhibiting post-menopausal bone loss or bone resorption in a post-menopausal woman in need of treatment to prevent or to treat post-menopausal osteoporosis comprising administering to a human said woman in need thereof of said treatment a compound of formula I or a pharmaceutically acceptable salt or solvate thereof, in an amount of about 50 to about 150 55 to 65 mg/day.
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Abstract
A method of inhibiting bone loss or resorption, or lowering serum cholesterol, comprising administering to a human in need thereof a compound having the formula
or a pharmaceutically acceptable salt or solvate thereof, in a low dosage amount. Also encompassed by the invention is a a pharmaceutical formulation in unit dosage form comprising, per unit dosage, a low dosage amount.
49 Citations
15 Claims
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1. A method of inhibiting post-menopausal bone loss or bone resorption in a post-menopausal woman in need of treatment to prevent or to treat post-menopausal osteoporosis comprising administering to a human said woman in need thereof of said treatment a compound of formula I
or a pharmaceutically acceptable salt or solvate thereof, in an amount of about 50 to about 150 55 to 65 mg/day.
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14. A method of preventing post-menopausal osteoporosis in a post-menopausal woman in need of treatment to prevent post-menopausal osteoporosis comprising administering to said woman a hydrochloride salt of a compound of Formula I
in an amount of 60 mg/day.
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15. A method of treating post-menopausal osteoporosis in a post-menopausal woman in need of treatment for post-menopausal osteoporosis comprising administering to said woman a hydrochloride salt of a compound of Formula I
in an amount of 60 mg/day.
Specification
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- Resources
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Current AssigneeEli Lilly and Company
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Original AssigneeEli Lilly and Company
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InventorsBlack, Larry J., Draper, Michael W.
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Primary Examiner(s)Webman, Edward J.
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Application NumberUS10/375,274Time in Patent Office1,125 DaysField of Search514/333, 514/422, 514/578, 514/443, 514/448US Class Current514/443CPC Class CodesA61K 31/445 Non condensed piperidines, ...A61K 31/4535 containing a heterocyclic r...
