Nude mouse model for human neoplastic disease

  • US RE39,337 E1
  • Filed: 02/13/1998
  • Issued: 10/10/2006
  • Est. Priority Date: 10/05/1988
  • Status: Expired due to Term
First Claim
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1. A nude mouse model for progression of human neoplastic disease, the progression of said disease being characterized by growth of a primary tumor site and metastasis to secondary tumor sites, wherein said mouse is characterized byhaving has histologically intact human neoplastic tissue of at least 1 mm3 in size transplanted onto an organ of said mouse which corresponds to the human organ from which said tissue is originally obtained;

  • and havinghas sufficient immuno-deficiency to allow said transplanted neoplastic tissue to grow andat said primary site and metastasize to said secondary tumor sites, so as to mimic the progression of the neoplastic disease including the metastatic behavior of said neoplastic disease in the human donorhumans.

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