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Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain

  • US RE41,288 E1
  • Filed: 08/06/2004
  • Issued: 04/27/2010
  • Est. Priority Date: 10/08/1998
  • Status: Expired due to Term
First Claim
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1. A method of increasing insulinotropic response in ischemia treating reperfusion-injured brain cells after an ischemic event comprising administering a composition containing glucagon-like peptide-1 (GLP-1) and a pharmaceutical carrier for a time sufficient and under conditions effective to increase insulinotropic response which produces insulin, with the produced insulin being neuroprotective by direct neurotropic effects and by controlling stroke-related hyperglycemia treat reperfusion injury.

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