Process for producing imide compound

• US RE45,573 E1
• Filed: 12/20/2013
• Issued: 06/23/2015
• Est. Priority Date: 07/29/2003
• Status: Active Grant

• Current Assignee: Sumitomo Pharmaceuticals Company Limited (Sumitomo Chemical Company Limited)
• Original Assignee: Sumitomo Dainippon Pharma Company Limited (Sumitomo Chemical Company Limited)
• Inventors: Kakiya, Yuzo, Oda, Mayumi
• Primary Examiner(s): JARRELL, NOBLE E
• Application Number:
  US14/137,464
• Time in Patent Office: 550 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: C07D 295/00 Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
• CPC Class Codes: C07D 401/14 containing three or more hetero rings
• CPC Class Codes: C07D 417/12 linked by a chain containing hetero atoms as chain links

Abstract

The present invention provides an excellent industrial process for producing an imide compound hydrochloride.

The process for producing an imide compound hydrochloride of the formula (2):

or an enantiomer thereof,
which comprises treating a compound of the formula (1):

or an enantiomer thereof with an aqueous hydrochloric acid solution in a hydrophilic solvent, followed by crystallizing the resultant.

Claims

1. A process for producing an imide compound hydrochloride of the formula (2):

2. The process for producing the imide compound hydrochloride according to claim 1, wherein the aqueous hydrochloric acid solution is a 3.0-5.0% aqueous hydrochloric acid solution.

3. The imide compound hydrochloride of the formula (2)

4. The imide compound hydrochloride as set forth in claim 3, which has a residual acetone content of about 0.1% by weight or less.

5. The imide compound hydrochloride as set forth in claim 3, which has impurities of about 0.1% by weight or less.

6. The imide compound hydrochloride as set forth in claim 3, which has a residual acetone content of about 0.1% by weight or less, and which has impurities of about 0.1% by weight or less.

7. A process for producing an imide compound hydrochloride of the formula (2):

8. The process for producing the imide compound hydrochloride according to claim 7, wherein the aqueous hydrochloric acid solution is a 3.0-5.0% aqueous hydrochloric acid solution.

9. The imide compound hydrochloride of the formula (2)

10. The imide compound hydrochloride as set forth in claim 9, which has a residual acetone content of about 0.1% by weight or less.

11. The imide compound hydrochloride as set forth in claim 9, which has impurities of about 0.1% by weight or less.

12. The imide compound hydrochloride as set forth in claim 9, which has a residual acetone content of about 0.1% by weight or less, and which has impurities of about 0.1% by weight or less.