Formulation of 'Duyiwei' with improved bioavailability and drug effect and preparation process thereof

Formulation of 'Duyiwei' with improved bioavailability and drug effect and preparation process thereof

  • CN 100,355,417 C
  • Filed: 09/13/2004
  • Issued: 12/19/2007
  • Est. Priority Date: 09/13/2004
  • Status: Active Grant
First Claim
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1. , a kind of common lamiophlomis root preparation preparation method, used medical material is:

  • Radix Lamiophlomidis Rotatae is characterized in that;

    the supplementary product consumption when making drop pill is weight set of dispense ratio;

    the dried cream powder of Radix Lamiophlomidis Rotatae extract is 1 part;

    drop pill substrate is 0.8~

    5.0 part;

    Or the thick paste of Radix Lamiophlomidis Rotatae extract is 1 part;

    drop pill substrate is 1.0~

    6.0 parts;

    Make drop pill according to the following steps;

    The preparation of step 1. medicinal substances extract;

    (1). get Radix Lamiophlomidis Rotatae medical material weight 1000g, be ground into 20~

    60 order coarse powder, decoct three times, each 1.0~

    2.0 hours, for the first time amount of water was 5~

    16 times of medical material weight, and second and third time amount of water is 4~

    15 times of medical material weight;

    (2). collecting decoction, filter, it is 1.25 thick paste that filtrate is concentrated into relative density under 25 ℃

    of conditions, also is the medicinal substances extract thick paste of preparation drop pill or soft capsule;

    The preparation of step 2. drop pill;

    The drop pill preparation;

    get drop pill substrate heating and melting, the medicinal substances extract thick paste that adding step 1 makes is mix homogeneously with it, is incubated under 50 ℃



    90 ℃

    conditions, mix homogeneously, splash in the coolant and be shaped, remove liquid coolant and promptly get drop pill, or coated again technology is made coated drop pill;

    Substrate in its drop pill is Polyethylene Glycol 9300;

    Coolant in its drop pill is the weight set of dispense than methyl-silicone oil;

    liquid paraffin is 4;

    1;

    The mixture that keeps medicinal substances extract and substrate when dripping system is in 78 ℃

    , 95 centimetres of cooling column effective column lengths, and 10 ℃

    of liquid coolants are dripped 45 on fast every part of clock, dropper mouth external diameter 2.5mm, internal diameter 2.0mm, then dripping the drop pill of making does not have the tail of taking off, and outward appearance is bright and clean shaped.

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