Delayed release pharmaceutical composition containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol

Delayed release pharmaceutical composition containing 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol

  • CN 100,402,021 C
  • Filed: 10/22/2002
  • Issued: 07/16/2008
  • Est. Priority Date: 10/24/2001
  • Status: Active Grant
First Claim
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1. the slow pharmaceutical composition that discharges, it comprises 3-(3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol or its pharmaceutically useful salt in the substrate of the slow release property with active component, wherein said substrate comprises one or more hydrophilic or hydrophobic polymers as pharmaceutically useful substrate formation agent of 1 to 80% weight, and its release in vitro rate below when in buffer agent, measuring under the 75rpm and detecting, having with the UV spectrometer according to Ph.Eur with Ph.Eur. slurry method, wherein said buffer agent is 6.8 at 37 ℃

  • of following pH;

    After 0.5 hour, discharge, based on the active component of 100% weight, the 3-of 3-35% weight (3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol,After 1 hour, discharge 3-(3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol of 5-50% weight,After 2 hours, discharge 3-(3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol of 10-75% weight,After 3 hours, discharge 3-(3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol of 15-82% weight,After 6 hours, discharge 3-(3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol of 30-97% weight,After 12 hours, discharge above 3-(3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol of 50% weight,After 18 hours, discharge above 3-(3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol of 70% weight,After 24 hours, discharge above 3-(3-dimethylamino-1-ethyl-2-methyl-propyl group) phenol of 80% weight.

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