Bacterin of tabling gene of E type hepatitis virus

Bacterin of tabling gene of E type hepatitis virus

  • CN 100,438,907 C
  • Filed: 05/09/2003
  • Issued: 12/03/2008
  • Est. Priority Date: 05/09/2003
  • Status: Active Grant
First Claim
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1. , a kind of hepatitis E virus chimeric gene vaccine is characterized in that:

  • (i) it is that HEV ORF23 is inserted into plasmid pcDNA 3In the recombiant plasmid pcDNA that obtains 3-ORF23, its plasmid map are the plasmid maps shown in the accompanying drawing 1, and (ii) HEV ORF23 sequence is as follows;

    ATGCAGCTGT?TCTACTCTCG?TCCCGTCGTC?TCAGCCAATG?GCGAGCCGAC?50TGTTAAGCTT?TATACATCTG?TAGAGAATGC?TCAGCAGGAT?AAGGGTATTG?100CAATCCCGCA?TGACATCGAC?CTCGGGGAGT?CTCGTGTAGT?TATTCAGGAT?150TATGACAACC?AACATGAGCA?GGACCGACCG?ACACCTTCCC?CAGCCCCATC?200GCGCCCTTTT?TCTGTCCTCC?GAGCTAATGA?TGTGCTTTGG?CTTTCTTTCA?250CCGCTGCCGA?GTATGACCAG?TCCACTTACG?GCTCTTCGAC?CGGCCCAGTC?300TATGTCTCTG?ACTCTGTGAC?CTTGGTTAAT?GTTGCGACCG?GCGCGCAGGC?350CGTTGCCCGG?TCACTCGACT?GGACCAAGGT?CACACTTGAT?GGTCGCCCCC?400TTTCCACCAT?CCAGCAGCAT?TCAAAGACCT?TCTTTGTCCT?GCCGCTCCGC?450GGTAAGCTCT?CCTTTTGGGA?GGCAGGTACT?ACTAAAGCCG?GGTACCCTTA?500TAATTATAAC?ACCACTGCTA?GTGACCAACT?GCTCGTTGAG?AATGCCGCTG?550GGCATCGGGT?TGCTATTTCC?ACTTACACCA?CTAGCCTGGG?TGCTGGCCCC?600GTCTCTATTT?CCGCGGTTGC?TGTTTTAGCC?CCCCACTCCG?CGCTAGCATT?650GCTTGAGGAT?ACCATGGACT?ACCCTGCCCG?CGCCCATACT?TTCGATGACT?700TCTGCCCGGA?GTGCCGCCCC?CTTGGCCTCC?AGGGCTGTGC?TTTTCAGTCT?750ACTGTCGCTG?AGCTTCAGCG?CCTTAAGATG?AAGGTGGGTA?AAACTCGGGA?800GTTGAATTCG?GGTGGAATGA?ATAACATGTC?TTTTGCTGCG?CCCATGGGTT 850CGCGACCATG?CGCCCTCGGC?CTATTTTGCT?GTTGCTCCTC?ATGTTTCTGC 900CTATGCTGCC?CGCGACACCG?CCCGGTCAGC?CGTCTGGCCG?CCGTCGTGGG 950CGGCGCAGCG?GCGGTTCCGG?CGGTGGTTTC?TGGGGTGACC?GGGTTGATTC 1000TCAGCCCTTC?GCAATCCCCT?ATATTCATCC?AACCAACCCC?TTCGCCCCCG 1050ATGTCACCGC?TGCGGCCGGG?GCTGGACCTC?GTGTTCGCCA?ACCCGCCCGA 1100CCACTCGGCT?CCGCTTGGCG?TGACCAGGCC?CAGCGCCCCG?CCGCTGCCTC 1150ACGTCGTAGA?CCTACCACAG?CTGGGGCCGC?GCCGCTAA 1188。

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