Modified chimeric polyeptides with improved pharmacokinetic properties

Modified chimeric polyeptides with improved pharmacokinetic properties

  • CN 100,523,187 C
  • Filed: 05/23/2000
  • Issued: 08/05/2009
  • Est. Priority Date: 06/08/1999
  • Status: Active Grant
First Claim
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1. isolated nucleic acid molecule, its a kind of fusion polypeptide of encoding, this polypeptide has the vascular endothelial growth factor receptor composition that is connected with the multimerization composition, wherein(a) the vascular endothelial growth factor receptor composition is the immunoglobulin like domain 2 of first kind of vascular endothelial growth factor receptor, with the immunoglobulin like domain 3 of second kind of vascular endothelial growth factor receptor, and do not comprise any other vascular endothelial growth factor receptor structural domain;

  • (b) the multimerization composition is an immunoglobulin domains, andDescribed fusion polypeptide has the aminoacid sequence of Figure 21 A-21C, Figure 22 A-22C or Figure 24 A-24C.

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