Pharmaceutical tablet system that floats on gastric fluid for multipulse release of active substance, the system and the preparation of the enveloping substance of the system

Pharmaceutical tablet system that floats on gastric fluid for multipulse release of active substance, the system and the preparation of the enveloping substance of the system

  • CN 100,589,793 C
  • Filed: 03/18/2002
  • Issued: 02/17/2010
  • Est. Priority Date: 03/31/2001
  • Status: Active Grant
First Claim
Patent Images

1. , a kind of can be in gastric juice or on the gastric juice long-time buoyant medicinal tablets system, the material release period and not release period replace in the successive process and to discharge one or more pharmaceutically active substances, describedly comprise continuously that alternately at least 2 materials that separated period by 1 not release discharge period, thusThe tablet system is made up of the multilamellar label of putting into glass type encapsulation object;

  • Label by alternately continuously stacked release and not releasing layer form, formed the accumulation of layer, it comprises at least two releasing layers, non-release layer in the middle of clipping between these two releasing layers, each releasing layer is by forming with blended pharmaceutically acceptable excipient of at least a described active medicinal matter and/or carrier, each non-release layer is made up of pharmaceutically acceptable excipient and/or carrier, does not contain described active medicinal matter;

    Cup type encapsulation object is covered lower surface and the side that is put in label wherein, and exposes the upper surface of label,It is characterized in that;

    Cup type encapsulation object is formed by the compacting clinkering mixture that comprises medicinal hydrophobic substance and medicinal inert ground pigment for the medicinal tablets system provides buoyancy with respect to gastric juice;

    Hydrophobic substance is made up of fatty and/or wax material, can lump by suppression, and bulk density is less than gastric juice density;

    AndHave ground pigment less than the bulky powder density of gastric juice density,Wherein ground pigment is an aluminosilicate magnesium.

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