Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof

Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof

  • CN 101,005,830 B
  • Filed: 07/25/2005
  • Issued: 09/29/2010
  • Est. Priority Date: 08/13/2004
  • Status: Active Grant
First Claim
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1. prolongation release tablet, be included in pramipexole or its officinal salt in its substrate, described substrate comprises at least two kinds of non-water swelling polymer other, and wherein at least a for being selected from following anionic polymer in these at least two kinds of polymer:

  • acrylate copolymer, methacrylate polymer, methacrylic acid copolymer, alginate, carrageenin, arabic gum, xanthan gum, chitosan, carmethose, carboxymethylcellulose calcium;

    WithAt least a in these at least two kinds of polymer;

    combination, the polyalkylene oxide of copolymer, polyvinyl alcohol and the polyvinylpyrrolidone of alkylcellulose, hydroxy alkyl cellulose, hydroxyalkyl alkylcellulose, carboxyl alkyl cellulose ester, disaccharide, oligosaccharide and polysaccharide, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylpyrrolidone and vinylacetate for being selected from the neutral polymer basically of following non-pregelatinized Starch;

    And wherein said substrate comprises;

    (a) pramipexole or its salt 0.05-5 weight %(b) anionic water swelling polymer 0.25-25 weight %(c) neutral water swelling polymer 10-75 weight %(d) other excipient adds to 100 weight %.

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