Ion exchange purifying method of aminoglycoside antibiotics

Ion exchange purifying method of aminoglycoside antibiotics

  • CN 101,012,246 A
  • Filed: 12/20/2006
  • Published: 08/08/2007
  • Est. Priority Date: 12/20/2006
  • Status: Active Application
First Claim
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1. the ion exchange purifying method of an aminoglycoside antibiotics, it is characterized in that:

  • the solution that will contain aminoglycoside antibiotics, in the pH value is under 6.0~

    7.7 conditions, extremely saturated with cationic exchange resin adsorption, remove not take place the debris and the more weak impurity of adsorptive power of ion-exchange earlier with the washing that is no less than 2 times of amount of resin (V/V), use the eluent of 0.5~

    1.5mol/L concentration of 3~

    7 times of amount of resin (V/V) again, with 1~

    3 times of amount of resin/hour flow velocity (V/V) wash-out aminoglycoside antibiotics component, elutriant is at-0.06~

    0.095MPa, under 50~

    70 ℃

    of conditions, through decompression and solvent recovery, vacuum concentration, be dried to the aminoglycoside antibiotics product.

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