Prodrugs of HIV protease inhibitors

Prodrugs of HIV protease inhibitors

  • CN 101,023,090 A
  • Filed: 06/29/2005
  • Published: 08/22/2007
  • Est. Priority Date: 07/06/2004
  • Status: Active Application
First Claim
Patent Images

1. have formula (I), (II) or compound (III):

  • Or WhereinL 1Be a key ,-C (O)-or-C (O) O-;

    Wherein-carbonyl of C (O) O-part is connected on formula (I), (II) or the A (HI);

    L 2Be-(CR 1R 2) mM is 1,2,3,4 or 5;

    R 1When occurring, be independently selected from hydrogen and C at every turn 1-C 12Alkyl;

    R 2When occurring, be independently selected from hydrogen and C at every turn 1-C 12Alkyl;

    R 3Be hydrogen, C 1-C 12The alkyl or aryl alkyl;

    R 4Be hydrogen, C 1-C 12The alkyl or aryl alkyl;

    Q is 1 or 2;

    T is 1 or 2;

    M aBe M 1Or M 2M bBe M 1Or M 2M 1Be Na +, K +Or +N (R 5) (R 6) (R 7) (R 8);

    M 2Be Ca 2+, Ba 2+, Mg 2+, Zn 2+Or +N (R 9) (R 10) (R 11) (R 12);

    R 5Be hydrogen, alkyl, hydroxyalkyl, arylalkyl or-C (=NH) NH 2R 6Be hydrogen, alkyl, hydroxyalkyl or arylalkyl;

    R 7It is hydrogen or alkyl;

    R 8It is hydrogen or alkyl;

    Perhaps, R 5And R 6Form piperidine ring with the nitrogen-atoms that they connected;

    R 9Be-alkyl-N +(Z 1) (Z 2) (Z 3);

    R 10Be hydrogen, alkyl or aryl alkyl;

    R 11It is hydrogen or alkyl;

    R 12It is hydrogen or alkyl;

    Perhaps, R 9And R 11Form piperazine ring with the nitrogen-atoms that they connected;

    Z 1It is hydrogen or alkyl;

    Z 2It is hydrogen or alkyl;

    Z 3Be hydrogen, alkyl or aryl alkyl;

    And A is

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