Method of preparing pharmaceutical intermediate of (2S,4R)-4-hydroxy-N,N-dimethyl-2-pyrrolidineformamide

Method of preparing pharmaceutical intermediate of (2S,4R)-4-hydroxy-N,N-dimethyl-2-pyrrolidineformamide

  • CN 101,033,209 A
  • Filed: 03/09/2006
  • Published: 09/12/2007
  • Est. Priority Date: 03/09/2006
  • Status: Active Grant
First Claim
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1. , pharmaceutical intermediate (2S, 4R)-the 4-hydroxy-n, the preparation method of N-dimethyl-2-pyrrolidine formamide is characterized in that, is with (2S, 4R)-4-hydroxyl-2-pyrrolidinecarboxylic acid ester class (I) is a raw material, with dimethylamine reaction, obtain pharmaceutical intermediate (2S, 4R)-the 4-hydroxy-n, N-dimethyl-2-pyrrolidine formamide (II), its reaction formula is as follows:

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