Liposomal compositions of glucocorticoid and glucocorticoid derivatives

Liposomal compositions of glucocorticoid and glucocorticoid derivatives

  • CN 101,043,875 A
  • Filed: 09/11/2005
  • Published: 09/26/2007
  • Est. Priority Date: 09/09/2004
  • Status: Active Application
First Claim
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1. one kind contains the glucocorticoid (GC) that is encapsulated in the liposome or the pharmaceutical composition of GC derivant, and wherein, described GC or GC derivant are retained in the described liposome 6 months basically, and described GC or GC derivant are selected from:

  • I) have pKa be equal to or less than 11 and when pH7 logD be-2.5~

    1.5 amphiphilic alkalescence GC or GC derivant;

    Ii) have pKa greater than 3 and when the pH 7 logD be-2.5~

    1.5 amphipathic weak acid GC or GC derivant.

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