Medicinal composition for treating osteoporosis and preparations and application thereof

Medicinal composition for treating osteoporosis and preparations and application thereof

  • CN 101,057,885 B
  • Filed: 04/20/2006
  • Issued: 12/12/2012
  • Est. Priority Date: 04/20/2006
  • Status: Active Grant
First Claim
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1. treat the Chinese medicine composition that the osteoporosis activity composition is a Fructus Psoraleae total coumarins for one kind, mainly comprise two kinds of compositions of psoralen and isopsoralen, it is characterized in that said Fructus Psoraleae total coumarins is to obtain through following method for preparing:

  • Get Fructus Psoraleae medical material 2000g, Fructus Psoraleae total coumarins average content 2.07% in this Fructus Psoraleae medical material wherein became the Fructus Psoraleae pulverizing medicinal materials in the medicated powder of 40 mesh sieves;

    95% soak with ethanol after 24 hours percolation extract, be 1.10~

    1.15 concentrated solution with percolate relative density when being evaporated to 50 ℃

    for 60 ℃

    , adding 3 times of medical material bulking values is the 6000ml acetic acid ethyl dissolution;

    Get supernatant after the centrifugal remove impurity, add ZTC type macroporous adsorbent resin, stir to supernatant;

    70 ℃

    of water-baths volatilize solvent, and ZTC type macroporous adsorptive resins on the dry method is with distilled water and the remove impurity respectively of 35% ethanol;

    Use 60% ethanol-eluting resin column at last, collect eluent, 60 ℃

    ,-condition of 0.09MPa under concentrating under reduced pressure;

    60 ℃

    ,-0.09MPa under vacuum drying, pulverize, Fructus Psoraleae total coumarins sample 48.78g;

    Wherein the content of Fructus Psoraleae total coumarins is 82.0%, and the rate of transform of Fructus Psoraleae total coumarins is 74.07%.

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