Poly (lactide-co-glycolide)-based sustained release microcapsules comprising a polypeptide and a sugar

Poly (lactide-co-glycolide)-based sustained release microcapsules comprising a polypeptide and a sugar

  • CN 101,065,116 B
  • Filed: 04/15/2005
  • Issued: 11/19/2014
  • Est. Priority Date: 04/15/2004
  • Status: Active Grant
First Claim
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1. for the slow releasing composition of delivery of biologically active polypeptide within release time, comprise a kind of biocompatible polymer, a kind of biologically active polypeptide, with a kind of sugar, in the preparation process of described compositions, to comprising biologically active polypeptide, sugar, thereby in the mixture of polymer, add flocculating agent to form microgranule, described flocculating agent is that the ratio of silicone oil and silicone oil and polymer solvent is 1.5:

  • 1, wherein, described polymer solvent is dichloromethane, by hydrargyrum, press algoscopy to determine that the total hole volume of described compositions is 0.1 ml/g or still less, thereby provide a kind of release profiles, the maximum serum-concentration C of biologically active polypeptide that described release profiles has at deenergized period maxwith the biologically active polypeptide average serum concentration C having at deenergized period averatio be 3 or still less, Wherein said biocompatible polymer is the DLPLG4A of 50;

    50,Wherein said biologically active polypeptide be exenatide the 3%w/w that accounts for described slow releasing composition to 5%w/w, andWherein said sugar is sucrose, accounts for the 2%w/w of described slow releasing composition.

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