Cysteine engineered antibodies and conjugates

Cysteine engineered antibodies and conjugates

  • CN 101,065,151 B
  • Filed: 09/22/2005
  • Issued: 12/10/2014
  • Est. Priority Date: 09/23/2004
  • Status: Active Grant
First Claim
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1. cysteine engineered antibody, it is by following method preparation, the method comprises with free cysteine aminoacid replacement parental generation antibody heavy chain the 121st locational amino-acid residue, the antigen that wherein said parental generation antibody selective binding antigen and described cysteine engineered antibody selective binding are identical with the antigen of parental generation antibody institute combination, wherein said parental generation antibody is the anti-EphB2R antibody of huMAb4D5-8 (trastuzumab), 2H9 or the anti-MUC16 antibody of 3A5.

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