Vaccines against japanese encephalitis virus and west nile virus

Vaccines against japanese encephalitis virus and west nile virus

  • CN 101,084,010 B
  • Filed: 10/19/2005
  • Issued: 05/06/2015
  • Est. Priority Date: 10/20/2004
  • Status: Active Grant
First Claim
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1. the chimeric flavirirus of attenuation, it comprises yellow fever virus, wherein film and envelope protein substitute with the film of Japanese encephalitis virus or west nile virus and envelope protein, wherein said chimeric flavirirus comprises the sudden change in the aminoacid 60 of chimeric flavirirus memebrane protein when carrying out alternative with the film of Japanese encephalitis virus and envelope protein, described sudden change makes the arginine of the 60th amino acids at described memebrane protein be substituted by cysteine;

  • Or the sudden change comprised when carrying out alternative with the film of west nile virus and envelope protein in the aminoacid 66 of chimeric flavirirus memebrane protein, described sudden change makes the leucine of the 66th amino acids at described memebrane protein be substituted by proline, wherein said Japanese encephalitis virus is SA14-14-2 strain, and west nile virus is NY99 strain.

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