Method for analyzing lipoproteins

Method for analyzing lipoproteins

  • CN 101,107,519 B
  • Filed: 11/24/2005
  • Issued: 09/17/2014
  • Est. Priority Date: 11/24/2004
  • Status: Active Grant
First Claim
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1. a hdl particle analytical approach, said method comprising the steps of:

  • By contained plurality of classes lipoprotein in the separated experimenter'"'"'s sample of liquid chromatography, then detect VLDL, LDL in separated hdl particle and the signal of HDL;

    Suppose that every kind of hdl particle is comprised of the subclass that becomes swarming to infer forming with extra necessary peak from grappling peak, then with above-mentioned detection signal, calculate corresponding to the curve of approximation that becomes swarming summation,Described in wherein one or more, the wash-out position at grappling peak is determined by the wash-out position of observing in metabolic disease patient, and described patient'"'"'s lipoprotein metabolism shows that the magnitude range of VLDL, LDL and HDL is narrow,Wherein, middle VLDL grappling peak, middle LDL grappling peak and middle HDL grappling peak be the average VLDL size based on normal lipid middle-aged male crowd respectively, average LDL size and average HDL size definition, large VLDL grappling peak, little LDL grappling peak and little HDL grappling peak do not have based on lipoprotein lipase activity or the average VLDL size of extremely low case, average LDL size and average HDL size definition, the average HDL size definition of the case that greatly HDL grappling peak lacks based on cholesterol ester transfer protein, the average VLDL size definition of little VLDL grappling peak based on thering is the III type hyperlipidemia of ApoE2/2.

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