Process for the synthesis of azetidinones

Process for the synthesis of azetidinones

  • CN 101,119,966 A
  • Filed: 12/19/2005
  • Published: 02/06/2008
  • Est. Priority Date: 12/20/2004
  • Status: Active Application
First Claim
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1. method that is used to prepare azetidinone may further comprise the steps:

  • (1) β

    -(substituted-amino) acid amides, β

    -(substituted-amino) acid esters or β

    -(substituted-amino) mercaptan carbonic ether and following reagent react(2) at least a silylation agent and(3) at least a cyclizing agent, it is selected from(a) alkali metal carboxylate, quaternary ammonium carboxylate, quaternary ammonium hydroxide, quaternary ammonium alkoxide, quaternary ammonium aromatic series oxide compound with and hydrate, or(b) following reaction product;

    (i) reaction product of at least a quaternary ammonium halide and at least a alkali metal carboxylate;

    Or(ii) at least a chlorination quaternary ammonium, bromination quaternary ammonium or iodate quaternary ammonium and at least onePlant the reaction product of alkaline metal fluoride cpd,Wherein the quaternary ammonium of cyclizing agent part does not replace or independently is selected from 1-4 group replacement of alkyl, aralkyl and aralkyl-alkyl.

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