Process for the synthesis of azetidinones

Process for the synthesis of azetidinones

  • CN 101,119,966 B
  • Filed: 12/19/2005
  • Issued: 08/13/2014
  • Est. Priority Date: 12/20/2004
  • Status: Active Grant
First Claim
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1. for the preparation of a method for azetidinone, comprise the following steps:

  • β

    -(substituted-amino) acid amides of formula AA is reacted with at least one silicomethane agent and at least one cyclizing agent, and wherein said cyclizing agent is;

    (a) alkali metal carboxylate, quaternary ammonium carboxylate, quaternary ammonium hydroxide, quaternary ammonium alkoxide, quaternary ammonium aromatic series oxide compound with and hydrate, or(b) reaction product of at least one quaternary ammonium halide and at least one alkali metal carboxylate, wherein said quaternary ammonium halide is aliquat, quaternary ammonium bromides or quaternary ammonium iodide;

    Wherein the quaternary ammonium part of cyclizing agent does not replace or 1-4 group being independently selected from alkyl, aralkyl and aralkyl-alkyl replaces;

    AndWherein said formula AA compound is as follows;

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