Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines

Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines

  • CN 101,123,982 A
  • Filed: 01/26/2006
  • Published: 02/13/2008
  • Est. Priority Date: 01/28/2005
  • Status: Active Application
First Claim
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1. strengthen method to the antigenic direct or follow-up immunne response in the bacterin preparation, it comprises uses the antigenic step with adjuvant, solution and described adjuvant that described adjuvant is included in the nitrous oxide gas that the medicine acceptable carrier solvent that is used for nitrous oxide gas prepares comprise at least a fatty acid or its ester or other suitable derivants, described fatty acid or its ester or derivant are selected from oleic acid, linoleic acid, alpha-linolenic acid, gamma-Linolenic acid, arachidonic acid, eicosapentaenoic acid [C20:

  • 5 ω

    3], docosahexenoic acid [C22;

    6 ω

    3], castor oil acid and derivant thereof, described derivant are selected from its C1 to C6 Arrcostab, its glycerol-macrogol ester and the hydrogenation natural oil that is mainly become by the line of oils based on castor oil acid is the product of Oleum Ricini and oxirane for example.

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