Compositions and methods for enhancing contrast in imaging

Compositions and methods for enhancing contrast in imaging

  • CN 101,123,996 B
  • Filed: 01/12/2005
  • Issued: 07/16/2014
  • Est. Priority Date: 04/21/2004
  • Status: Active Grant
First Claim
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1. for the manufacture of a method for the liposome composition that contains contrast-enhancing agents, the method comprises the following steps:

  • A) comparative selection degree reinforcing agent;

    B) concentrated contrast-enhancing agents;

    C) under contrast-enhancing agents exists, form liposome, wherein said liposome comprise cholesterol, at least one carbon chain lengths be the phospholipid of 14-24 carbon atom and with at least one carbon chain lengths that hydrophilic polymer chains derives be the phospholipid of 14-24 carbon atom;

    D) concentrated liposome;

    Wherein the average diameter of prepared liposome is lower than 150nm, and coated at least one concentration of wherein said liposome exceedes the on-radiation contrast-enhancing agents of the iodate of 85mg I/mL liposome suspension.

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