A preparation method of memantine bi-sulfur bi-nitrogen derivates medicinal box marking by technetium

A preparation method of memantine bi-sulfur bi-nitrogen derivates medicinal box marking by technetium

  • CN 101,156,953 A
  • Filed: 11/16/2007
  • Published: 04/09/2008
  • Est. Priority Date: 11/16/2007
  • Status: Active Application
First Claim
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1. one kind 99mTc-N-[2-(N-(2-mercaptoethyl)) glycyl]-N-(2-mercaptoethyl)-3,5-dimethyladamantane amino acetamide medicine box is called for short 99mThe Tc-NCAM medicine box, preparation method, it is characterized in that preparation process is:

  • (1) N-[2-(N-(2-mercaptoethyl)) glycyl]-N-(2-mercaptoethyl)-3, the preparation of 5-dimethyladamantane amino acetamide medicine box;

    Take by weighing 1.8g Na 2HPO 412H 2O and 0.2g KH 2PO 4Be dissolved in the 70mL water, add 0.20-2.0g gluceptate sodium and 20-400mg ethylenediaminetetraacetic acid again, add 50.0-2000.0mg/L SnF 2The hydrochloric acid solution 10.0mL of 0.1M in, the methanol solution 10.0mL that adds 70% concentration of 200.0-2000.0mg/L NCAM at last, add distilled water again to cumulative volume 100mL, aseptic filtration behind the mixing, be sub-packed in the 10mL specification cillin bottle by the 1.00mL/ bottle, promptly get the NCAM medicine box after the lyophilization, contain 20-200 μ

    gNCAM, 5-200 μ

    g SnF in every medicine box 22H 2O, 0.2-4mg ethylenediaminetetraacetic acid, 2-20mg gluceptate sodium and pH are at the 4.0-7.0 phosphate buffer;

    (2) 99mTc labeling kit;

    freeze dried NCAM medicine box, the Na of the 50-1000MBq of adding drip washing 99mTcO 4Solution 1.0mL places heating 30min postcooling on the boiling water bath, is 99mTc-N-[2-(N-(2-mercaptoethyl)) glycyl]-N-(2-mercaptoethyl)-3,5-dimethyladamantane amino acetamide medicine box.

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