Absorbable/biodegradable composite yarns and property-modulated surgical implants therefrom
Absorbable/biodegradable composite yarns and property-modulated surgical implants therefrom
- CN 101,163,451 B
- Filed: 04/20/2006
- Issued: 04/16/2014
- Est. Priority Date: 04/26/2005
- Status: Active Grant
- EN CH
-
- Pin
First Claim
Patent Images
1. absorbable/biodegradable surgical implant, it comprises at least the first and second cellulosic components, described cellulosic component has different absorption distributions in biotic environment and different strength retention ratios distributes, described the first and second cellulosic components are plied multifilament yarns of the first and second separately continuous yarns, andWherein said first separately continuously yarn comprise end be grafted to 95/5 in multiaxis PTMC (mole) copolymer and described second of the mixture of Acetic acid, hydroxy-, bimol. cyclic ester/6-caprolactone separately continuously yarn comprise 84/11/5 (mole) copolymer of the mixture of 1-lactide/trimethylene carbonate/caprolactone.
Abstract
The present invention is directed to absorbable/biodegradable composite yarns, each comprising at least two types of fibrous components having distinctly different absorption and strength retention profiles and the use of these composite yarns to construct surgical implants, such as sutures and meshes with integrated physicochemical and biological properties, modulated through varying the individual yarn content and controlling the geometry of these constructs.
24 Claims
-
1. absorbable/biodegradable surgical implant, it comprises at least the first and second cellulosic components, described cellulosic component has different absorption distributions in biotic environment and different strength retention ratios distributes, described the first and second cellulosic components are plied multifilament yarns of the first and second separately continuous yarns, and
Wherein said first separately continuously yarn comprise end be grafted to 95/5 in multiaxis PTMC (mole) copolymer and described second of the mixture of Acetic acid, hydroxy-, bimol. cyclic ester/6-caprolactone separately continuously yarn comprise 84/11/5 (mole) copolymer of the mixture of 1-lactide/trimethylene carbonate/caprolactone.
-
2. absorbable/biodegradable surgical implant, it comprises at least the first and second cellulosic components, described cellulosic component has different absorption distributions in biotic environment and different strength retention ratios distributes, described the first and second cellulosic components are plied multifilament yarns of the first and second separately continuous yarns, and
Wherein said first separately continuously yarn comprise end be grafted to 95/5 in multiaxis PTMC (mole) copolymer and described second of the mixture of Acetic acid, hydroxy-, bimol. cyclic ester/6-caprolactone separately continuously yarn comprise 88/12 (mole) copolymer of the mixture of 1-lactide/trimethylene carbonate.
-
3. absorbable/biodegradable surgical implant described in claim 1 or 2, described absorbable/biodegradable surgical implant is braided suture form.
-
4. absorbable/biodegradable surgical implant described in claim 1 or 2, described absorbable/biodegradable surgical implant is the knitting net structural form of using during hernia is repaired.
-
5. absorbable/biodegradable surgical implant described in claim 1 or 2, described absorbable/biodegradable surgical implant is woven net structural form.
-
6. absorbable/biodegradable surgical implant as described in claim 3, wherein said stitching thread also comprises coating, and described coating comprises absorbable polymer to improve constraint character and to make to organize tractive to minimize.
-
7. absorbable/biodegradable surgical implant as described in claim 4, wherein said net also comprises face coat, and described coating comprises absorbable polymer to regulate for the structure permeability of biofluid with to the tissue ingrowth in described structure.
-
8. absorbable/biodegradable surgical implant as described in claim 5, wherein said net also comprises face coat, and described coating comprises absorbable polymer to regulate for the structure permeability of biofluid with to the tissue ingrowth in described structure.
-
9. absorbable/biodegradable surgical implant as described in claim 3, wherein said stitching thread comprises the core being obtained by the first yarn and the sheath being obtained by the second yarn, and wherein the first yarn is different from the second yarn.
-
10. absorbable/biodegradable surgical implant described in claim 1 or 2, described absorbable/biodegradable surgical implant is to repair as the hernia of organizational project the device form that paster is used.
-
11. absorbable/biodegradable surgical implants described in claim 1 or 2, described absorbable/biodegradable surgical implant is the device form as tendon, ligament or vascular graft.
-
12. absorbable/biodegradable surgical implants described in claim 1 or 2, the form that described absorbable/biodegradable surgical implant is tubular knitted net.
-
13. absorbable/biodegradable surgical implants as described in claim 12, wherein said net also comprises thin absorbable film insert.
-
14. absorbable/biodegradable surgical implants as described in claim 13, wherein said net and described film insert be the compression used in hernia is repaired, three-layer tablet columnar structure form.
-
15. absorbable/biodegradable surgical implants as described in claim 14, wherein three-layer tablet columnar structure also comprises absorbable coating.
-
16. absorbable/biodegradable surgical implants described in claim 1 or 2, also comprise the absorbable polyester coating that contains bioactivator, the group that described bioactivator selects free antimicrobial, analgesic, antineoplastic agent, anti-inflammatory agent and growth promoter to form.
-
17. absorbable/biodegradable surgical implants described in claim 1 or 2, at least one in wherein said cellulosic component comprises multifilament and at least one comprises monofilament yarn.
-
18. absorbable/biodegradable surgical implants as described in claim 17, described absorbable/biodegradable surgical implant is flat knit net form coating or uncoated.
-
19. absorbable/biodegradable surgical implants as described in claim 17, described absorbable/biodegradable surgical implant is coating or uncoated through compiling net form.
-
20. absorbable/biodegradable surgical implants as described in claim 17, described absorbable/biodegradable surgical implant is woven net form coating or uncoated.
-
21. absorbable/biodegradable surgical implants as described in claim 17, described absorbable/biodegradable surgical implant is for hernia reparation, vascular tissue reparation, produces the device form of vascular graft or organizational project.
-
22. absorbable/biodegradable surgical implants as described in claim 17, described absorbable/biodegradable surgical implant is coating or the uncoated suture form that comprises monofilament core and braiding sheath.
-
23. absorbable/biodegradable surgical implants as described in claim 17, also comprise and contain the coating that fusion temperature is less than the absorbable polyester of 100 ℃
- .
-
24. absorbable/biodegradable surgical implants described in claim 23, wherein said coating comprises at least one bioactivator, the group that described bioactivator selects free antimicrobial, anti-inflammatory agent, antineoplastic agent, anesthetis and growth promoter to form.
Specification(s)