Functions and uses of GPR39 gene in mammalian central nervous system

Functions and uses of GPR39 gene in mammalian central nervous system

  • CN 101,166,540 A
  • Filed: 04/24/2006
  • Published: 04/23/2008
  • Est. Priority Date: 04/22/2005
  • Status: Active Application
First Claim
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1. a kind of GPR39 albumen of mammal or the purposes of its activator or antagonist, it is characterised in that health products or pharmaceutical composition for preparing regulation and control mammalian appetite or the pain sensation.purposes as claimed in claim 1, it is characterised in that described pharmaceutical composition contains the mammal GPR39 albumen and pharmaceutically acceptable carrier of safe and effective amount;

  • OrDescribed pharmaceutical composition contains the mammal GPR39 protein antagonists and pharmaceutically acceptable carrier of safe and effective amount.Power3. purposes as claimed in claim 1, it is characterised in that described GPR39 albumen is selected from the group the GPR39 albumen of animal:

    People, rat and mouse.4. purposes as claimed in claim 1, it is characterised in that described pharmaceutical composition contains (the ^1% &

    of 0. 01- 9139 albumen, are based on the total weight of the composition.Ask5. purposes as claimed in claim 1, it is characterised in that described health products or the formulation of pharmaceutical composition are tablet, capsule, granule or solution.6. the health products or pharmaceutical composition of a kind of appetite-suppressing or the pain sensation, it is characterised in that it contains the mammal GPR39 protein antagonists and bromatology or pharmaceutically acceptable carrier of safe and effective amount.7. a kind of method for the drug candidate for screening reduction appetite or the pain sensation, it is characterised in that it includes step:

    (1) cDNA of GPR39 genes is loaded into expression vector, transfection mammalian cell strain prepares the cell line of expression GPR39 albumen:

    (2) to step(

    1) test compound is added in the cell line nutrient solution of the expression GPR39 albumen in, the change of GPR39 expressing quantities is detected;

    It is exactly to reduce the drug candidate of appetite or the pain sensation to suppress the increased compound of GPR39 expressing quantities.8. method as claimed in claim 7, it is characterised in that described GPR39 albumen has SEQ ID NO;

    2nd, the amino acid sequence shown in 4 or 6.9. a kind of method for screening the drug candidate for improving appetite or the pain sensation, it is characterised in that it includes step:

    (1) cDNA of GPR39 genes is loaded into expression vector, transfection mammalian cell strain prepares the cell line of expression GPR39 albumen:

    (2) to step(

    1) test compound is added in the cell line nutrient solution of the expression GPR39 albumen in, the change of GPR39 expressing quantities is detected;

    It is exactly to improve food to promote the increased compound of GPR39 expressing quantitiesThe drug candidate of desire or the pain sensation.10. method as claimed in claim 9, it is characterised in that described GPR39 albumen has SEQ ID NO;

    2nd, the amino acid sequence shown in 4 or 6.

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