Cytotoxic agents comprising new maytansinoids

Cytotoxic agents comprising new maytansinoids

  • CN 101,186,613 A
  • Filed: 05/20/2004
  • Published: 05/28/2008
  • Est. Priority Date: 05/20/2003
  • Status: Active Application
First Claim
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1. CHROMATOGRAPHIC FRACTIONATION AND MASS;

  • it is at C-3;

    the C-14 methylol;

    C-15 hydroxyl or C-20 demethyl place;

    amino acid side chain with acidylate;

    this side chain has carboxyl groups;

    this carboxyl groups has and has the sterically hindered sulfydryl;

    the acyl group carbon atom that wherein has the thiol function base has one or two substituting group;

    described substituting group is linear alkyl or the thiazolinyl with 1 to 10 carbon atom;

    ramose or cyclic alkyl or alkenyl with 3 to 10 carbon atoms;

    phenyl;

    the phenyl that replaces;

    or alkoxyl group;

    halogen or nitro;

    or heterocyclic aryl or heterocyclic radical;

    in addition;

    one of substituting group can be H, and wherein said carboxyl groups has the linear chain length of at least 3 carbon atoms between carbonyl functional group and sulphur atom.

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