Method for preparing benzoylpyridine derivatices and salt thereof

Method for preparing benzoylpyridine derivatices and salt thereof

  • CN 101,215,260 B
  • Filed: 10/29/2004
  • Issued: 07/09/2014
  • Est. Priority Date: 10/31/2003
  • Status: Active Grant
First Claim
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1. The manufacture method of 1.3-(2,3,4-trimethoxy-6-methyl benzoyl) the chloro-2-methoxyl group-4-of-5-picoline,Be the method being made up of following operation, described operation is,(a) the 1st operation, it is in 1,2-ethylene dichloride, to make the chloro-2-methoxyl group-4-methylnicotinic acid of 5-and chlorination reaction, obtains the operation of the chloro-2-methoxyl group-4-of 5-methylnicotinic acid acyl chlorides;

  • With(b) the 2nd operation;

    it is the 5-chloro-2-methoxyl group-4-methylnicotinic acid acyl chlorides and 3 by obtaining in the 1st operation;


    the Friedel-Crafts reaction of 5-trimethoxytoluene;

    obtain the operation of 3-(2,3,4-trimethoxy-6-methyl benzoyl) the chloro-2-methoxyl group-4-of-5-picoline;

    described Friedel-Crafts reaction carries out in 1,2-ethylene dichloride.

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