Pharmaceutical compositions containing sc(Fv)2

Pharmaceutical compositions containing sc(Fv)2

  • CN 101,262,885 B
  • Filed: 06/09/2006
  • Issued: 04/01/2015
  • Est. Priority Date: 06/10/2005
  • Status: Active Grant
First Claim
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1. the pharmaceutical composition of the sc (Fv) 2 containing stabilisation, described sc (Fv) 2 is containing two variable region of heavy chain VH1 and VH2 and two variable region of light chain VL1 and VL2, salt and pH adjusting agent is with the addition of in this pharmaceutical composition, wherein salt is sodium chloride or magnesium chloride, wherein, the concentration of described salt is 150mM to 300mM, and wherein said pH adjusting agent is sodium citrate buffer solution or histidine hydrochloride, and pH is 6.0-9.0Wherein in described pharmaceutical composition, isomerization between two kinds of conformers is suppressed, wherein said two kinds of conformers are single-chain diabodies type sc (Fv) 2 or bivalent scFv type conformer, wherein in described single-chain diabodies type sc (Fv) 2, VH1 and VL2 assembles, and VH2 and VL1 assembles.

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