Method for designing ribonucleic acid molecule with multiple steadiness structures

Method for designing ribonucleic acid molecule with multiple steadiness structures

  • CN 101,281,560 A
  • Filed: 06/05/2008
  • Published: 10/08/2008
  • Est. Priority Date: 06/05/2008
  • Status: Active Application
First Claim
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1. a design has the method for the ribonucleic acid molecule of multiple steadiness structures, it is characterized in that design problem that described method at first will have a ribonucleic acid molecule of multiple steadiness structures is converted into the combinatorial optimization problem in the ribonucleic acid molecule set compatible with predetermined structure, on this basis, employing further is converted into this problem the painted problem of point on the dependency graph based on the mathematical model of graph theory.Specifically comprise the following steps:

  • 1) reception is differentiated its legitimacy from the predetermined secondary structure set of terminal;

    2) generate dependency graph;

    3) bisectability of check dependency graph;

    4) decompose dependency graph;

    5) counting and uniform sampling in the consistent sequence set;

    6) select cost function model and parameter;

    7) optimize candidate sequence.

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