Compounds for the treatement of metabolic disorders

Compounds for the treatement of metabolic disorders

  • CN 101,304,740 A
  • Filed: 11/09/2006
  • Published: 11/12/2008
  • Est. Priority Date: 11/09/2005
  • Status: Active Application
First Claim
Patent Images

1. the bioactivator purposes aspect the preparation medicine, described medicine is used for the treatment of the disease that is selected from the group of being made up of insulin resistance syndrome, the diabetes that comprise type i diabetes and type ii diabetes and polycystic ovarian syndrome;

  • Or be used for the treatment of the atherosclerosis relevant, arteriosclerosis, obesity, vascular hypertension, hyperlipemia, fatty liver disease, nephropathy, neuropathy, retinopathy with diabetes, foot festers or cataract or reduce these advancing of disease chances;

    Or be used for the treatment of the disease that is selected from the group of forming by hyperlipemia, cachexia and obesity;

    Wherein said activating agent is a following formula;

    compound;

    Formula I Wherein;

    N is 1 or 2;

    One of m and x are 0, and another is 0,1,2,3 or 4;

    Q is 0 or 1;

    T is 0 or 1;

    R 2It is alkyl with 1~

    3 carbon atom;

    R 3Be hydrogen, halogen, have the alkyl of 1~

    3 carbon atom or have the alkoxyl of 1~

    3 carbon atom;

    R 4And R 5One of be alkyl with 1~

    3 carbon atom, another is hydrogen or the alkyl with 1~

    3 carbon atom;

    A does not have substituent phenyl or has in the following radicals of being selected from 1 or 2 groups as substituent phenyl;

    halogen, the alkyl with 1 or 2 carbon atom, perfluoro-methyl, the alkoxyl with 1 or 2 carbon atom and perfluor methoxyl group;

    Perhaps A is the cycloalkyl with 3~

    6 ring carbon atoms, and wherein said cycloalkyl does not have substituent group or one or two ring carbon is replaced by methyl or ethyl list independently;

    Perhaps A has 1 or 2 five yuan or six-membered Hetero-aromatic that is selected from the ring hetero atom of N, S and O, and described hetero-aromatic ring is covalently bound by the remainder of ring carbon and formula I chemical compound;

    AndR 1Be hydrogen or alkyl with 1 or 2 carbon atom;

    Perhaps work as R 1When being hydrogen, described bioactivator is the pharmaceutically useful salt of described chemical compound.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×