RNAi-mediated inhibition of Rho kinase for treatment of ocular disorders

RNAi-mediated inhibition of Rho kinase for treatment of ocular disorders

  • CN 101,326,285 A
  • Filed: 12/19/2006
  • Published: 12/17/2008
  • Est. Priority Date: 12/27/2005
  • Status: Active Application
First Claim
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1. weaken the method that Rho kinases mRNA expresses among the experimenter, it comprises:

  • The experimenter used comprise the RNA interfering with 19 to 49 length of nucleotides of significant quantity and the composition of pharmaceutically acceptable carrier, described RNA interfering comprises;

    Adopted nucleotide chain, antisense nucleotide chain and the approaching at least zone of at least 19 Nucleotide of complementary are fully continuously arranged;

    Wherein antisense strand under physiological condition with corresponding to the part hybridization of the mRNA of SEQ ID NO;

    1 or SEQ ID NO;

    2 and have respectively with corresponding to the hybridization portion of the mRNA of SEQ ID NO;

    1 or SEQ ID NO;

    2 at least near the zone of at least 19 Nucleotide of complementary fully continuouslyWherein weaken the expression of Rho kinases mRNA thus.

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