Stable preparation method of decitabine freeze-dry preparation

Stable preparation method of decitabine freeze-dry preparation

  • CN 101,361,718 A
  • Filed: 09/26/2008
  • Published: 02/11/2009
  • Est. Priority Date: 09/26/2008
  • Status: Active Application
First Claim
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1. the preparation method of a stable decitabine freeze-dried comprises the steps:

  • (1) decitabine is dispersed in the organic solvent tert-butyl alcohol, ethanol, methanol or be dissolved at least a in the organic solvent dimethyl sulfoxide;

    (2) again with water for injection or to have dissolved the water for injection of lyophilizing proppant and/or PH regulator miscible, described organic solvent accounts for 5~

    80% of this mixed liquor volume;

    (3) filter, organic solution is removed in lyophilization.

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