Immunogenic compositions and methods of use

Immunogenic compositions and methods of use

  • CN 101,365,724 A
  • Filed: 10/25/2006
  • Published: 02/11/2009
  • Est. Priority Date: 10/25/2005
  • Status: Active Application
First Claim
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1. method of producing multilayer film, described film comprises the first layer and the second layer, and wherein adjacent layers comprises the polyelectrolyte of oppositely charged, and described method comprises:

  • Covalent attachment one or more surface adsorption district and one or more functional zone, to generate complex polypeptide, wherein said complex polypeptide and described one or more surface adsorption district have identical polar,Wherein said one or more surface adsorption district comprises one or more aminoacid sequence motifs, and described motif is made up of 5 to 15 amino-acid residues and has net charge intensity/residue more than or equal to 0.4 under neutral pH, andWherein said one or more functional zone comprise 3 to about 250 amino-acid residues,Wherein said complex polypeptide is not a homopolymer, and length is at least 15 amino-acid residues, and has the water solubility greater than 50 μ

    g/mL in pH 4 to 10 scopes;

    AndDescribed complex polypeptide is deposited on the matrix or the described second layer, to form the first layer;

    The wherein said second layer comprises second layer polyelectrolyte, described second layer polyelectrolyte comprises polycation material or polyanion material, described polycation material or polyanion material have greater than 1,000 molecular weight and at least 5 electric charges of each molecule, and one with the opposite electric charge of described the first layer polyelectrolyte.

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