The method and composition of targeting polyubiquitin

The method and composition of targeting polyubiquitin

  • CN 101,374,862 B
  • Filed: 12/14/2006
  • Issued: 12/16/2015
  • Est. Priority Date: 12/15/2005
  • Status: Active Grant
First Claim
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1. the antibody be separated of the polyubiquitin specific binding connected with Methionin-48, wherein this antibody comprises six hypervariable region (HVR) sequences, wherein HVR-H1, HVR-H2, HVR-H3 and HVR-L3 sequence corresponds in Figure 10 A-10C apu01, apu02, apu03, apu04, apu05, apu06, apu07, apu08, apu09, apu10, apu11, apu12, apu13, to apu2.01 in listed or Figure 16 A and 16B of apu14 or apu15, apu2.02, apu2.03, apu2.04, apu2.05, apu2.06, apu2.07, apu2.08, HVR-H1 listed by apu2.09 or apu2.10, HVR-H2, HVR-H3 and HVR-L3 sequence, HVR-L1 sequence corresponds to SEQIDNO:

  • 79, and HVR-L2 sequence corresponds to SEQIDNO;

    80, wherein said HVR-H1, HVR-H2, the aminoacid sequence of HVR-H3 with HVR-L3 is from identical clone.

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