Method of preparing ketorolac ammonia butanetriol key intermediate

Method of preparing ketorolac ammonia butanetriol key intermediate

  • CN 101,508,646 A
  • Filed: 04/02/2009
  • Published: 08/19/2009
  • Est. Priority Date: 04/02/2009
  • Status: Active Application
First Claim
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1. method for preparing methane tricarboxylic acid triethyl, its technological process is as follows:

  • Iodine causes magnesium and ethanol synthesis, and magnesium ethylate that is generated and diethyl malonate IV reaction obtain ethoxy magnesium propylmalonic acid diethyl ester V, obtains triethyl carboxylic acid methyl magnesium chloride VI with the Vinyl chloroformate reaction again, through acidifying, alkaline purification obtains methane tricarboxylic acid triethyl I, and reaction formula is as follows;

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