Dosage form for providing ascending dose of drug

Dosage form for providing ascending dose of drug

  • CN 101,518,517 B
  • Filed: 08/08/1997
  • Issued: 11/26/2014
  • Est. Priority Date: 08/16/1996
  • Status: Active Grant
First Claim
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1. medicinal tablet, comprises the core that chamber forms:

  • It comprises;

    A) contain the ground floor of the medicine of 10ng-300mg dosage and the hydrophilic polymer of 5mg-250mg;

    B) containing the medicine of 50ng-500mg dosage and the second layer of 25mg-450mg hydrophilic polymer, the described second layer contains the medicine higher than the larger dose of described ground floor;

    WithC), containing the 3rd layer of the hydrophilic polymer of 15ng-450mg, described the 3rd layer provides support from delivering drugs wherein for ground floor and second layer order;

    Wherein the second layer contains and medicine identical in ground floor, and wherein said medicine is selected from amfetamine, methamphetamine, methylphenidate, piperazine vinegar methylol ester, piperazine vinegar ethyl ester, amphetamine and azoxodone, and described the 3rd layer does not contain medicine;

    Wherein the described hydrophilic polymer in first and second layers contains and has poly-(alkylene oxide) that number-average molecular weight is 40000-1000000, described hydrophilic polymer in the 3rd layer contains and has poly-(alkylene oxide) that number-average molecular weight is 2000000-10000000, andDescribed first and second layers further contain the hydroxypropyl emthylcellulose that number-average molecular weight is 9000-750000;

    Around the semi-permeable wall with sealing the core of described chamber formation, wherein said wall can see through liquid but can not see through medicine;

    The outlet forming in semi-permeable wall, its position at the described ground floor of next-door neighbour passes into the described chamber forming core heart, to allow medicine to be released into environment for use from tablet;

    WithCover layer, it contains the medicine that 100ng-100mg is identical with first and second layers on described wall outer surface;

    The speed that wherein said medicine continued to increase with the unit interval discharges the time of an elongated segment from tablet.

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