The preparation and medication of protein matrix vaccines and this vaccine

The preparation and medication of protein matrix vaccines and this vaccine

  • CN 101,553,246 B
  • Filed: 08/07/2007
  • Issued: 05/21/2019
  • Est. Priority Date: 08/07/2006
  • Status: Active Grant
First Claim
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1. the method for preparing vaccine composition, the composition include the antigen contained by carrier protein matrix, the antigen withThe albumen substrate noncovalent associations, which comprises(I) mixes the target antigen selected from polysaccharide, polyalcohol and polyaminoacid homopolymer with carrier protein;

  • It is wherein described polynaryAlcohol is the hydrogenated form of carbohydrate, and carbonyl has been reduced into primary hydroxyl or secondary hydroxyl;

    WithThe connector for being crosslinked the carrier protein by the sulfydryl, amino or carboxyl of carrier protein molecule is added in (II), and(iii) it is crosslinked the carrier protein and forms carrier protein matrix.

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