Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life

Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life

  • CN 101,557,830 A
  • Filed: 12/14/2007
  • Published: 10/14/2009
  • Est. Priority Date: 12/15/2006
  • Status: Active Application
First Claim
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1. protein construct, it comprises:

  • (a) activated factor VII (FVIIa) molecule, it is selected from the group that biologically active derivatives constituted by plasma F VIIa, reorganization FVIIa (rFVIIa) and FVIIa;

    And(b) the acceptable carbohydrate moiety of at least one physiology, it comprises 1-4 sialic acid unit that is incorporated into described FVIIa molecule;

    Wherein, compare with the half-life in the body of the FVIIa molecule that is not incorporated into described carbohydrate moiety, the half-life is extended in the body of described construct in mammalian.

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