For the polymer of functional particles

For the polymer of functional particles

  • CN 101,573,141 B
  • Filed: 05/15/2007
  • Issued: 05/04/2016
  • Est. Priority Date: 05/15/2006
  • Status: Active Grant
First Claim
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1. a composition, it comprises:

  • Particle, described particle comprises amphiphilic macromolecular, and described large molecule contains the first hydrophobicity portionPoint, the second hydrophilic parts and Part III, described the first hydrophobic parts, the second hydrophily portionPoint or the two comprise biocompatible polymer, described Part III comprises and is selected from targeting moiety, one-tenthThe structural portion of picture part, chelating moiety, the part with multiple charged groups and therapeutic partPoint, wherein said particle has the described Part III of higher concentration in its surface, and in instituteState structure division and have in described particle the concentration of non-zero substantially, described non-zero substantially refers toDescribed granule interior exist can detection limit compound;

    Wherein said particle is made by the method that comprises following steps;

    Provide and contain described macromolecular solution;

    AndDescribed solution is contacted with polymer non-solvent, and wherein said Macromolecular self-assembly is to produce instituteState particle.

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