Method for preparing a polymer conjugate

Method for preparing a polymer conjugate

  • CN 101,583,380 A
  • Filed: 11/30/2007
  • Published: 11/18/2009
  • Est. Priority Date: 11/30/2006
  • Status: Active Application
First Claim
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1. one kind with polyethylene glycol polymer and the covalently bound method of activating agent, said method comprising the steps of:

  • The activating agent that comprises first functional group is provided, described first functional group be selected from amino, hydroxyl and carboxyl andIn the presence of coupling agent and p-methyl benzenesulfonic acid 4-(dimethylamino)-pyridiniujm (DPTS), effectively promoting under the condition of the reaction between described first functional group and second functional group, with described activating agent with comprise the Polyethylene Glycol reaction that described first functional group is had reactive second functional group, thereby form Polyethylene Glycol-activating agent conjugates.

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