anti-CD 16 binding molecules

anti-CD 16 binding molecules

  • CN 101,583,625 B
  • Filed: 05/26/2006
  • Issued: 03/20/2020
  • Est. Priority Date: 05/26/2005
  • Status: Active Grant
First Claim
Patent Images

1. An antibody or antigen-binding fragment thereof having specificity for at least one antigen, wherein the at least one antigen is Fc γ

  • RIIIA, which antibody or antigen-binding fragment thereof does not specifically bind to Fc γ

    RIIIB and comprises a light chain variable region and a heavy chain variable region, wherein;

    the heavy chain variable region comprises the amino acid sequence set forth as SEQ ID NO;

    17, heavy chain CDR1 of SEQ ID NO;

    18 and a heavy chain CDR2 of SEQ id no;

    19 heavy chain CDR 3; and

    the light chain variable region comprises a CDR1, CDR2, and CDR3 selected from the group consisting of;

    (i) is SEQ ID NO;

    20 CDR1 of SEQ ID NO;

    21 and CDR2 of SEQ ID NO;

    22 CDR 3;

    (ii) is SEQ ID NO;

    23 CDR1 of SEQ ID NO;

    24 and CDR2 of SEQ ID NO;

    25 CDR 3;

    (iii) is SEQ ID NO;

    26 CDR1 of SEQ ID NO;

    27 and CDR2 of SEQ ID NO;

    28 CDR 3;

    (iv) is SEQ ID NO;

    29 CDR1 of SEQ ID NO;

    30 and CDR2 of SEQ ID NO;

    22 CDR 3;

    (v) is SEQ ID NO;

    26 CDR1 of SEQ ID NO;

    31 and CDR2 of SEQ ID NO;

    32 CDR 3;

    (vi) is SEQ ID NO;

    33 CDR1 of SEQ ID NO;

    21 and CDR2 of SEQ ID NO;

    22 CDR 3;

    (vii) is SEQ ID NO;

    34 CDR1 of SEQ ID NO;

    35CDR2 and SEQ ID NO;

    22 CDR 3.

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