Process for the preparation of pleuromutilins

Process for the preparation of pleuromutilins

  • CN 101,595,090 B
  • Filed: 10/03/2007
  • Issued: 12/24/2014
  • Est. Priority Date: 10/05/2006
  • Status: Active Grant
First Claim
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1. , for the preparation of the method for 14-O-[(N-3-methyl-2-(R)-amino-butyryl-piperidine-3 (S)-Ji) sulfanyl ethanoyl] mutilins, said method comprising the steps of:

  • A) 14-O-[(piperidines-3 (S)-Ji) sulfanyl ethanoyl] the mutilins deprotection of N-protected is made; and

    the 14-O-of separated free form or acid addition salt form thereof [(piperidines-3 (S)-Ji) sulfanyl ethanoyl] mutilinsB) with protected for enamine and by activation be carbonic acid mixed acid anhydride (R)-α

    -amino-isovaleric acid acidylate step a) in obtain 14-O-[(piperidines-3 (S)-Ji) sulfanyl ethanoyl] mutilins,C) step b is made) the middle compound deprotection obtained, and be separated 14-O-[(N-3-methyl-2-(R)-amino-butyryl-piperidine-3 (S)-Ji) sulfanyl ethanoyl] mutilins.

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