Rnase and toxalbumin membrane transposition structural domain fusion rotein and its production and use

Rnase and toxalbumin membrane transposition structural domain fusion rotein and its production and use

  • CN 101,613,410 B
  • Filed: 06/25/2008
  • Issued: 01/20/2016
  • Est. Priority Date: 06/25/2008
  • Status: Active Grant
First Claim
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1. a fusion rotein, is characterized in that, described fusion rotein is made up of following:

  • (1) rnase;

    (2) membrane transposition structural domain of bacterial poison albumen;

    (3) be positioned between (1) and (2) by the connection peptides of 0-50 Amino acid profile;

    It is active and enter the ability of tumour cell kytoplasm that wherein said fusion rotein has the good knubble biological that kills;

    Wherein, the aminoacid sequence of described fusion rotein is as shown in SEQIDNO;

    2.

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