Polypeptide films and methods

Polypeptide films and methods

  • CN 101,641,086 B
  • Filed: 01/22/2008
  • Issued: 04/22/2015
  • Est. Priority Date: 01/22/2007
  • Status: Active Grant
First Claim
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1. a multilayer film, this film contains two or more polyelectrolyte layer, and wherein, adjacent layer contains the polyelectrolyte of oppositely charged;

  • Wherein the first polyelectrolyte layer is the first layer polypeptide containing one or more first amino acid sequence motif;

    Wherein said one or more first amino acid sequence motif is made up of 5-15 amino acid residue, and the net charge of each amino acid residue is for being more than or equal to 0.4;

    Wherein said first layer polypeptide has at least 15 amino acid residues long, and during pH7.0, each residue has the net charge being more than or equal to 0.4;

    Wherein said first layer polypeptide contains to hold with its N-or therapeutic agent that C-holds reversible covalent to be connected;

    The second layer is greater than 1 containing molecular weight, 000 and the polycationic material of each molecular band at least 5 electric charges or the second polyelectrolyte layer of polyanionic material, and wherein, the described second layer is not containing polypeptide;

    AndWherein said polypeptide is not same aggressiveness.

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