Vector for gene therapy

Vector for gene therapy

  • CN 101,663,397 B
  • Filed: 04/16/2008
  • Issued: 04/22/2015
  • Est. Priority Date: 04/20/2007
  • Status: Active Grant
First Claim
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1. one kind comprises the retroviral vector of transcription unit, described transcription unit comprises transcriptional regulatory sequences and the gene with the polypeptide of single stranded RNA specific ribonucleic acid endonuclease activity of encoding, described gene is placed like this, thus its expression can be controlled by described adjustment sequence, wherein said unit is placed like this, thus make from the transcriptional orientation of the mRNA of described unit contrary with the transcriptional orientation of the rna gene group of described retroviral vectorWherein said transcriptional regulatory sequences is such transcriptional regulatory sequences, thus makes to transcribe by Tat protein induce.

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