Gentamycin sulfate tablets and preparation method thereof

Gentamycin sulfate tablets and preparation method thereof

  • CN 101,664,392 B
  • Filed: 09/28/2009
  • Issued: 01/30/2013
  • Est. Priority Date: 09/28/2009
  • Status: Active Grant
First Claim
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1. gentamycin sulfate tablets, it is characterized in that principal agent is the gentamycin sulfate of standard measure, ratio of adjuvant is mass percent:

  • starch 40~

    70%, microcrystalline Cellulose 1~

    10%, calcium sulfate 10~

    30%, PEG6000 1~

    10%, surplus are lubricant;

    The preparation method of gentamycin sulfate tablets is carried out according to the following steps;

    (1) takes by weighing starch, microcrystalline Cellulose, calcium sulfate, PEG6000 by formula ratio, cross respectively 80 mesh sieves;

    (2) with starch, microcrystalline Cellulose, calcium sulfate and gentamycin sulfate raw material mix homogeneously;

    (3) PEG6000 is dissolved in 75~

    95% the alcoholic solution preparation working concentration 5~

    15% and makes binding agent, soft material processed, granulation;

    (4) wet granular is dry under 55~

    80 ℃

    of temperature conditions, and granulate adds lubricant, and mixing is measured dried granule moisture content with KETT, control dried granule moisture content 1.0~

    6.0% with interior tabletting.

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