The weight of determining coating to be administered is to form the method for controlled release form

The weight of determining coating to be administered is to form the method for controlled release form

  • CN 101,668,513 A
  • Filed: 02/06/2008
  • Published: 03/10/2010
  • Est. Priority Date: 02/23/2007
  • Status: Active Application
First Claim
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1. , a kind of coating comprises the particulate method spherical in shape basically of beta-Blocking agent chemical compound;

  • described granule spherical in shape does not basically have blemish basically;

    thereby and have thin film and form coating to provide thin film to control the release of described beta-Blocking agent from the described granule spherical in shape basically with predetermined release rate on the described granule spherical in shape basically, described method comprises;

    (a) in a collection of granule spherical in shape basically, determine the surface area of the described particulate sample of weighing spherical in shape basically;

    (b) determine the weight of the coating material on the granule per unit surface area spherical in shape basically, thereby be the coating level that granule spherical in shape basically provides compositions described in the step (a), provide required release profile for described beta-Blocking agent thus;

    (c) determine the particulate surface area that next group is spherical in shape basically, the beta-Blocking agent that is comprised in the beta-Blocking agent that described granule comprises and the granule spherical in shape basically applied in step (b) is identical;

    (d) be used in the coating of using in the step (b) and be coated with described next group granule spherical in shape basically, thereby on the granule spherical in shape basically of described next group, provide coating, wherein the described coating on the described new a collection of spheroidal particle have with determined particulate per unit surface area spherical in shape basically in step (b) on the coating material of substantially the same weight.

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