Variant being derived by ACTRIIB and uses thereof

Variant being derived by ACTRIIB and uses thereof

  • CN 101,679,505 B
  • Filed: 02/04/2008
  • Issued: 05/25/2016
  • Est. Priority Date: 02/02/2007
  • Status: Active Grant
First Claim
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1. a modification A ctRIIB albumen, wherein said albumen:

  • (i) originate in 20,21,22,23,24 or 25 of SEQIDNO;

    2;

    (ii) end at 128,129,130,131,132,133 or 134 of SEQIDNO;

    2;

    And(iii) contain acidic amino acid at 79 bit positions corresponding to SEQIDNO;

    2;

    Wherein said modification A ctRIIB albumen suppresses the letter via myostatin and/or GDF11 in cellular type is measuredNumber transduction.

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